Journal
JOURNAL OF NATURAL PRODUCTS
Volume 78, Issue 6, Pages 1390-1396Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00284
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Funding
- National Research Foundation of Korea (NRF) grant - Korean government (Ministry of ICT and Future Planning) [2009-0083533]
- Marine Biotechnology Program (Genome Analysis of Marine Organisms and Development of Functional Applications) - Ministry of Oceans and Fisheries, Korea [PJT200620]
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A marine-derived Streptomyces strain, SSC21, was isolated from the sediment of Suncheon Bay, Republic of Korea. Chemical analysis of the bacterial strain resulted in the isolation of four new metabolites, suncheonosides A-D (1-4, respectively), each bearing a,sulfur atom. The planar structures of the suncheonosides were identified as hexasubstituted benzothioate glycosides by combined spectroscopic analyses. Analysis of the configuration of the sugar moieties based on ROESY nuclear magnetic resonance correlations, one-bond H-1-C-13 coupling constant analysis, and chemical derivatizations indicated that the suncheonosides incorporate only L-rhamnose. Suncheonosides A, 13, and ID promoted adiponectin production in a concentration-dependent manner during adipogenesis in human mesenthymal stein cells, suggesting antidiabetic potential.
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