Journal
JOURNAL OF NATURAL PRODUCTS
Volume 78, Issue 6, Pages 1243-1252Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00025
Keywords
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Funding
- National Natural Science Foundation [81273398]
- Ministry of Science and Technology of the People's Republic of China [2012CB721105]
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Sixteen new limonoids, named ciparasins A-P (1-16), comprising three Structural categories of trijugin-type (1-7), cipadesin-type and prieurianin-type (16) compounds, as well as 15 known limonoid analogues (17-31), were isolated from Cipadessa cinerascens. Ciparasins E-G (5-7) were found to possess a rare gamma-hydroxylbutenolide moiety at C-17. Ciparasins 13 (2) and P (16) showed significant anti-HIV activities, with EC50 values of 5.5 +/- 0.6 (Si >7.2) and 6.1 +/- 0.7 (SI > 6.5) mu M, respectively.
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