Journal
JOURNAL OF NATURAL PRODUCTS
Volume 78, Issue 5, Pages 1037-1044Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np5010196
Keywords
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Funding
- NBRPC (973) [2014CB138703]
- NNSFC [31270396]
- 111 Project of China
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Nine new terpenoids (1-3, 5-10), including three cyclolanostane triterpenoids (1-3) and six isopimarane diterpenoids (5-10), along with six known terpenoids (4, 11-15), were isolated from the leaves and twigs of Dysoxylum gotadhora. Compound 1 represents a class of rare natural 21,24-epoxy cyclolanostane-type triterpenoids, and compounds 2 and 3 are the first examples of 21,25-epoxy cyclolanostane-type triterpenoids. Compounds 1, 2, 4, 8, and 15 exhibited noteworthy inhibition of nitric oxide production induced by lipopolysaccharide in RAW 264.7 cells with IC50 values of 25.5, 41.5, 27.4, 14.5, and 45.2 mu M, respectively.
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