Journal
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume 87, Issue 3, Pages 265-282Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2013.01.007
Keywords
Glioblastoma; Phase III trials; Recurrent glioblastomas; Elderly patients; Prognostic factors
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Glioblastomas (GBMs) are invariably associated with unavoidable tumor recurrence and overall poor prognosis. The present study is to summarize the results of clinical Phase III studies on GBMs over the past seven years. A systematic literature search was performed using major electronic databases and by screening meeting abstracts. Totally, 16 studies of patients with newly diagnosed GBMs;recurrent GBMs, and elderly patients with GBMs were selected for this review. Although the outcomes of the experimental therapies were not encouraging, these studies produced a considerable amount of potentially clinically relevant information. Such aspects as surgical outcomes, radiation schedules, temozolomide (TMZ) schedules, methylation status of the O6-methylguanine DNA methyltransferase (MGMT) gene, combination of therapies, novel drug delivery methods and use of targeted agents have come to light and are being addressed here. In addition, we discuss the existing controversies of (1) surgical studies, (2) evaluations of recurrence, (3) salvage treatment bias, and (4) studies on elderly patients. (c) 2013 Elsevier Ireland Ltd. All rights reserved.
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