Journal
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume 88, Issue 3, Pages 706-715Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2013.09.001
Keywords
Nrf2; Radioresistance; ROS; Antioxidant; Targeted therapy
Categories
Funding
- Chinese National Natural Science Foundation [NSFC 81301922, 81302055]
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Radiation therapy can effectively kill cancer cells through ROS generation. Cancer cells with upregulated antioxidant systems can develop high radioresistance ability, and the transcription factor NF-E2-related factor 2 (Nrf2) is a key regulator of the antioxidant system. Currently, there are numerous data indicating the important role of Nrf2 in cancer radioresistance. In this review, we summarize the aberrant regulation of Nrf2 in radioresistant cells and discuss the effects and underlying mechanism of Nrf2 in promoting radioresistance. These findings suggest that Nrf2 might be a potential therapeutic target in cancer radiation resistance or a promising radioprotector for normal organs during radiation therapy in the future. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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