Journal
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume 78, Issue 2, Pages 138-149Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2010.04.003
Keywords
Cancer treatment; Functional status; Frail elderly; Geriatric oncology; Geriatric assessment; Prospective cohort study; Treatment toxicity
Categories
Funding
- Canadian Cancer Society/National Cancer Institute of Canada
- Solidage McGill University/Universite de Montreal Research Group on Frailty and Aging
- McGill Dr. Joseph Kaufman Chair in Geriatric Medicine
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Introduction: The concept of frailty may be useful to characterize vulnerability. The aim of this pilot study was to explore the association between frailty/functional status and treatment toxicity at 3 months and mortality at 6 months. Methods: Patients aged >= 65 years referred to the Jewish General Hospital, Montreal, with a new cancer diagnosis. Seven frailty markers and 4 functional status measures were examined. Logistic regression was used to examine the association between frailty/functional status and toxicity, and Cox models for time to death. Results: 112 participated, median age 74.1, 31 had toxicity and 15 died. At baseline, 88% had >= 1 frailty marker. Low grip strength predicted toxicity (OR 8.47, 95%CI: 1.3-53.6), ECOG performance status and ADL disability predicted time to death. Conclusion: The majority had >= 1 frailty marker. Low grip strength predicted toxicity, none of the functional measures did. Further researcher investigating the usefulness of frailty markers is needed. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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