Journal
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume 70, Issue 3, Pages 262-271Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2008.07.017
Keywords
Taxanes; Elderly; Schedule; Pharmacokinetics
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Funding
- Sandro Pitigliani Foundation
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Taxanes are very effective agents in several types of cancer. However, their activity is counterbalanced by side effects that could represent a limitation of their use in older cancer patients. This review aims at evaluating whether or not there are data supporting a tailored use of standard taxanes i.e. docetaxel and paclitaxel in elderly patients with the aim to increase their therapeutic index. In addition, recent data on the role of nanoparticle albumine-bound paclitaxel in breast cancer are discussed in this paper. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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