Journal
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume 67, Issue 3, Pages 213-228Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2008.02.006
Keywords
peptide-targeted; radionuclide therapy; melanoma
Categories
Funding
- National Cancer Institute P50 Imaging Center [P50-CA-103130]
- Department of Energy [DOE-FG0296ER61661]
- UNM-LANL MOU [2R76T]
- American Foundation for Pharmaceutical Education [3R48E]
- American Cancer Society Institutional Research [IRG-92-024]
- New Mexico Technology Research Collaborative [3R44N]
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Melanocortin-1 receptor (MC1-R) and melanin are two attractive melanoma-specific targets for peptide-targeted radionuclide therapy for melanoma. Radiolabeled peptides targeting MC1-R/melanin can selectively and specifically target cytotoxic radiation generated from therapeutic radionuclides to melanoma cells for cell killing, while sparing the normal tissues and organs. This review highlights the recent advances of peptide-targeted radionuclide therapy of melanoma targeting MC1-R and melanin. The promising therapeutic efficacies of Re-188-(Arg(11))CCMSH (Re-188-[CyS3,4,10, D-Phe(7),Arg(11)]-alpha-MSH3-13), Lu-177- and Pb-212-labeled DOTA-Re(Arg(11))CCMSH (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-[ReO-(Cys(3,4,10) D-Phe(7), Arg(11))]-alpha-MSH3-13) and Re-188-HYNIC-4B4 (Re-188-hydrazinonicotinamide-Tyr-Glu-Arg-Lys-Phe-Trp-His-Gly-Arg-His) in preclinical melanoma-bearing models demonstrate an optimistic outlook for peptide-targeted radionuclide therapy for melanoma. Peptide-targeted radionuclide therapy for melanoma will likely contribute in an adjuvant setting, once the primary tumor has been surgically removed, to treat metastatic deposits and for treatment of end-stage disease. The lack of effective treatments for metastatic melanoma and end-stage disease underscores the necessity to develop and implement new treatment strategies, such as peptide-targeted radionuclide therapy. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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