Journal
CRITICAL REVIEWS IN MICROBIOLOGY
Volume 42, Issue 2, Pages 293-309Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1040841X.2014.940495
Keywords
Antiseptics; biofilms; iodine; pH; silver
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Funding
- Engineering and Physical Sciences Research Council [1566856] Funding Source: researchfish
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Biofilm recalcitrance is a persistent problem when managing difficult to heal and infected chronic wounds. The wound biofilm is a fundamental factor in the re-occurrence and delayed healing commonly observed in non-healing and infected chronic wounds. However, there is presently no single antimicrobial agent that is completely efficacious against both the planktonic and sessile polymicrobial communities evident in at risk or infected wounds. We will review currently available antimicrobials, with particular emphasis on silver and iodine, employed to help suppress biofilms in wounds. In addition, we will also review the effect of pH on antimicrobial efficacy. Available evidence suggests that it is best to take a multifactorial approach towards controlling biofilm in chronic, at risk and infected wounds. This highlights the growing importance of avoiding indiscriminate or inappropriate use of antimicrobials in the treatment of chronic wounds.
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