Journal
CRITICAL REVIEWS IN MICROBIOLOGY
Volume 39, Issue 1, Pages 79-101Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1040841X.2012.691460
Keywords
CTX-M; cefotaximase; extended-spectrum beta-lactamase (ESBL); ISEcp1; ISCR1; plasmid
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Funding
- Ministry of Education, Culture, Sports, Science [24591489]
- Informa Healthcare USA, Inc. Technology, Japan
- Showa University Medical Foundation, Tokyo, Japan
- Grants-in-Aid for Scientific Research [24591489] Funding Source: KAKEN
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CTX-M enzymes, the plasmid-mediated cefotaximases, constitute a rapidly growing family of extended-spectrum beta-lactamases (ESBLs) with significant clinical impact. CTX-Ms are found in at least 26 bacterial species, particularly in Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis. At least 109 members in CTX-M family are identified and can be divided into seven clusters based on their phylogeny. CTX-M-15 and CTX-M-14 are the most dominant variants. Chromosome-encoded intrinsic cefotaximases in Kluyvera spp. are proposed to be the progenitors of CTX-Ms, while ISEcp1, ISCR1 and plasmid are closely associated with their mobilization and dissemination.
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