Journal
CRITICAL REVIEWS IN MICROBIOLOGY
Volume 39, Issue 3, Pages 247-255Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1040841X.2012.706250
Keywords
Coculture; 2-keto-L-gulonic acid; Ketogulonicigenium vulgare; metabolomics
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Funding
- National Natural Science Foundation of China [20836003]
- Program for New Century Excellent Talents in University [NCET-10-0456]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Program for Advanced Talents within Six Industries of Jiangsu Province [2011-NY033]
- 111 Project [111-2-06]
- Fundamental Research Funds for the Central Universities [JUDCF10017]
- Jiangsu Province Natural Science Funds for Distinguished Young Scholars [BK2012002]
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At present, the modern two-step fermentation process is one of the major approaches for the industrial production of vitamin C. The key step in this process is the conversion of L-sorbose to 2-keto-L-gulonicacid (2-KLG), the vitamin C precursor, which is accomplished by an artificial microbial ecosystem consisting of Ketogulonicigenium vulgare and Bacillus megaterium. This review describes current progress in understanding this ecosystem, not only the individual physiological characteristics of the two strains, but also the interactions between them. Special emphasis is placed on recent systems biology studies of the ecosystem. We also discuss the regulation and improvement of this ecosystem, including analysis of the fermentation medium components and genetic engineering and optimum fermentative strategies. Finally, perspectives on the knowledge and engineering of this important artificial microbial ecosystem are discussed.
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