Journal
CRITICAL REVIEWS IN MICROBIOLOGY
Volume 38, Issue 1, Pages 30-51Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1040841X.2011.621064
Keywords
Acinetobacter; Acinetobacter-derived cephalosporinase (ADC); carbapenem-hydrolysing class D beta-lactamase (CHDL); integron; insertion sequence (IS)
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Funding
- Grants-in-Aid for Scientific Research [24591489] Funding Source: KAKEN
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Innate resistance and remarkable ability to acquire additional resistance determinants underline the clinical importance of Acinetobacter. Over 210 beta-lactamases belonging to 16 families have been identified in the genus, mostly in clinical isolates of A. baumannii. In this review, we update the current taxonomy of the genus Acinetobacter and summarize the beta-lactamases detected in Acinetobacter spp. with an emphasis on Acinetobacter-derived cephalosporinases (ADCs) and carbapenem-hydrolysing class D beta-lactamases (CHDLs). We also discuss the roles of integrons and insertion sequence (IS) elements in the expression and dissemination of such resistance determinants.
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