Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 15, Issue 6, Pages 4136-4142Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2015.9602
Keywords
Mesenchymal Stem Cells; Nanotube Dimension; Osteoclasts; Osteoporosis; Titania Nanotube
Categories
Funding
- National Natural Science Foundation of China [81271934]
- Specialized Research Fund for the Health Industry of the Ministry of Health [201002018]
- Fundamental Research Funds for the Central Universities [2013YGYL017]
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Implants that can inhibit osteoclastogenesis and enhance osteogenesis are desirable for osteoporosis patients. In this study, titania nanotube (Ti-NT) materials, having nanotube diameters of 30, 80, and 120 nm, were produced separately by anodization at 10, 40, and 60 V, respectively. The introduction of Ti-NTs to titanium substrates significantly reduced the formation and activity of osteoclasts on samples. With the enlargement of the nanotube diameter, the osteoclasts number, tartrate-resistant acid phosphatase staining and activity, and related gene expressions of osteoclasts were further reduced. Osteogenic ability was enhanced by increasing the nanotube diameter. Thus, larger-diameter nanotube implants, such as NT60, were better able to inhibit bone absorption and enhance bone formation to prevent implant loss and failure, especially for osteoporosis patients.
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