Journal
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
Volume 52, Issue 6, Pages 525-532Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2010.503288
Keywords
phytochemical; chemoprevention; cruciferous vegetable; diet and cancer prevention; isothiocyanate quantitation
Categories
Funding
- National Cancer Institute [R01CA124627]
- NATIONAL CANCER INSTITUTE [R01CA124627] Funding Source: NIH RePORTER
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Many naturally occurring isothiocyanates (ITCs) show highly promising chemopreventive activities. Humans are commonly exposed to these compounds through the consumption of cruciferous vegetables which are the main source of dietary ITCs. Dietary ITCs may play an important role in cancer prevention and in the well-recognized cancer preventive activities of cruciferous vegetables. A generic analytical method, namely the 1,2-benzenedithiol-based cyclocondensation assay, was previously developed for quantitation of ITCs and their in vivo metabolites. This method has been widely used and has contributed greatly to research on chemoprevention by ITCs. In this article, the discovery and development of the cyclocondensation assay are recapitulated, and its sensitivity and specificity as well as its advantages and limitations are scrutinized. Moreover, detailed discussion is also provided to show how this assay has been used to advance our understanding of the cancer chemopreventive potential and the mechanism of action of ITCs.
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