Journal
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
Volume 50, Issue 5, Pages 420-440Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10408390802304230
Keywords
diet; supplementation; blood concentration; vitamin E; prospective study; randomized clinical trial; meta-analysis
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Funding
- Gran Mariscal de Ayacucho Foundation
- German Academic Exchange Service
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Cardiovascular diseases are the leading cause of worldwide mortality. There is strong epidemiologic evidence for a beneficial effect of vitamin E on cardiovascular disease risk. However, conflicting results have been reported by intervention studies. To assess the potential benefit of vitamin E intake on the risk of cardiovascular diseases, fifty-nine published reports from observational studies, retrospective and prospective, randomised clinical trials, meta-analyses as well as pooling analyses were reviewed. The paper provides a detailed discussion about design, quality and limitations of these studies with regard to the evidence of the hypothesized relationship between vitamin E and cardiovascular diseases.
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