Journal
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION
Volume 20, Issue 2, Pages 141-148Publisher
BEGELL HOUSE INC
DOI: 10.1615/CritRevEukarGeneExpr.v20.i2.40
Keywords
microRNA; passenger strand; RISC
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Processing of the pre-microRNA (pre-miRNA) through Dicerl generates a miRNA duplex, consisting of a miRNA and miRNA* strand (also termed guide strand and passenger strand, respectively). Despite the general consensus that miRNA*s have no regulatory activity, recent publications have provided evidence that the abundance, possible function, and physiological relevance of miRNA*s have been underestimated. This review provides an account of our current understanding of miRNA* origination and activity, mounting evidence for their unique functions and regulatory mechanisms, and examples of specific miRNA*s from the literature.
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