Journal
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION
Volume 20, Issue 2, Pages 149-155Publisher
BEGELL HOUSE INC
DOI: 10.1615/CritRevEukarGeneExpr.v20.i2.50
Keywords
gene expression; nuclear structure; histone
Funding
- National Institutes of Health [P01 AR048818, P01 CA082834, 5 P30 DK32520]
- NATIONAL CANCER INSTITUTE [P01CA082834, R01CA139322] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [P01AR048818, R01AR049069, R01AR039588] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R37DE012528] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK032520] Funding Source: NIH RePORTER
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The regulatory machinery that governs genetic and epigenetic control of gene expression for biological processes and cancer is organized in nuclear microenvironments. Strategic placement of transcription factors at target gene promoters in punctate microenvironments of interphase nuclei supports scaffolding of coregulatory proteins and the convergence as well as integration of regulatory networks. The organization and localization of regulatory complexes within the nucleus can provide signatures that are linked to regulatory activity. Retention of transcription factors at gene loci in mitotic chromosomes contributes to epigenetic control of cell fate and lineage commitment, as well as to persistence of transformed and tumor phenotypes. Mechanistic understanding of the architectural assembly of regulatory machinery can serve as a basis for treating cancer with high specificity and minimal off-target effects.
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