Journal
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
Volume 50, Issue 3, Pages 65-78Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10408363.2013.805182
Keywords
Phytonutrients; polyphenols; pterostilbene; resveratrol; stilbenes
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Funding
- MINECO (Ministerio de Economia y Competitividad) [SAF2012-31565]
- Green Molecular S.L. (a startup company of the University of Valencia and CRB Inverbio), Spain
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Resveratrol and its naturally dimethylated analog, pterostilbene, show similar biological activities. However, the higher in vivo bioavailability of pterostilbene represents a fundamental advantage. The main focus of this review is on biomedical applications of pterostilbene. The metabolism and pharmacokinetics of this stilbene in inflammatory dermatoses and photoprotection, cancer prevention and therapy, insulin sensitivity, blood glycemia and lipid levels, cardiovascular diseases, aging, and memory and cognition are addressed. Safety and toxicity, as well as recommendations for future research and biomedical uses, are discussed. This review includes comparisons between pterostilbene and other polyphenols, with particular emphasis on resveratrol. Potential benefits of using combinations of different polyphenols are considered. Based on present evidences we conclude that pterostilbene is an active phytonutrient and also a potential drug with multiple biomedical applications.
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