Journal
CRITICAL REVIEWS IN BIOTECHNOLOGY
Volume 35, Issue 4, Pages 497-513Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/07388551.2014.904269
Keywords
Bio-based production; microbial fermentation; microbial platforms; non-food feedstocks; organic acids; renewable resources
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Microbial production of organic acids has become a fast-moving field due to the increasing role of these compounds as platform chemicals. In recent years, the portfolio of specialty fermentation-derived carboxylic acids has increased considerably, including the production of glyceric, glucaric, succinic, butyric, xylonic, fumaric, malic, itaconic, lactobionic, propionic and adipic acid through innovative fermentation strategies. This review summarizes recent trends in the use of novel microbial platforms as well as renewable and waste materials for efficient and cost-effective bio-based production of emerging high-value organic acids. Advances in the development of robust and efficient microbial bioprocesses for producing carboxylic acids from low-cost feedstocks are also discussed. The industrial market scenario is also reviewed, including the latest information on the stage of development for producing these emerging bio-products via large-scale fermentation.
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