Journal
CRITICAL REVIEWS IN BIOTECHNOLOGY
Volume 34, Issue 3, Pages 197-214Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/07388551.2013.778229
Keywords
Arachidonic acid; industrialization; lipid accumulation; Mortierella; oleaginous fungi; polyunsaturated fatty acid; triacylglycerol
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Funding
- National Science Foundation for Distinguished Young Scholars of China [21225626]
- National Basic Research Program of China [2011CBA00807, 2009CB724700]
- National Natural Science Foundation of China [20936002, 21006049]
- National High Technology Research and Development Program of China [2012AA02A702]
- National Key Technology Support Program of China [2011BAD23B03]
- Key Project of Jiangsu Natural Science Foundation [BK2011031]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT 1066]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Ministry of Education of China [NCET-09-0157]
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Fungal arachidonic acid (ARA)-rich oil is an important microbial oil that affects diverse physiological processes that impact normal health and chronic disease. In this article, the historic developments and technological achievements in fungal ARA-rich oil production in the past several years are reviewed. The biochemistry of ARA, ARA-rich oil synthesis and the accumulation mechanism are first introduced. Subsequently, the fermentation and downstream technologies are summarized. Furthermore, progress in the industrial production of ARA-rich oil is discussed. Finally, guidelines for future studies of fungal ARA-rich oil production are proposed in light of the current progress, challenges and trends in the field.
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