Journal
CRITICAL REVIEWS IN BIOTECHNOLOGY
Volume 32, Issue 4, Pages 374-381Publisher
INFORMA HEALTHCARE
DOI: 10.3109/07388551.2011.651428
Keywords
Propionic acid; microbial production; propionibacteria; reverse metabolic engineering; systematic metabolic engineering; acid tolerance; petrochemical synthesis
Categories
Funding
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- National Natural Science Foundation of China [20836003, 21006040]
- Major State Basic Research Development Program of China (973 Program) [2012CB720806]
- National High Technology Research and Development Program of China (863 Program) [2011AA100905]
- 111 Project [111-2-06]
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Propionic acid (PA) is an important building block chemical and finds a variety of applications in organic synthesis, food, feeding stuffs, perfume, paint and pharmaceutical industries. Presently, PA is mainly produced by petrochemical route. With the continuous increase in oil prices, public concern about environmental pollution, and the consumers' desire for bio-based natural and green ingredients in foods and pharmaceuticals, PA production from propionibacteria has attracted considerable attention, and substantial progresses have been made on microbial PA production. However, production of PA by propionibacteria is facing challenges such as severe inhibition of end-products during cell growth and the formation of by-products (acetic acid and succinic acid). The integration of reverse metabolic engineering and systematic metabolic engineering provides an opportunity to significantly improve the acid tolerance of propionibacteria and reduce the formation of by-products, and makes it feasible to strengthen the commercial competition of biotechnological PA production from propionibacteria to be comparable to the petrochemical route.
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