Journal
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume 44, Issue 1, Pages 34-49Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10409230802594043
Keywords
oxidative stress; UV; alkylation; RNA photoproducts; RNA crosslinking; RNA decay
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Funding
- NIH [GM073863]
- Ellison Medical Foundation.
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM073863] Funding Source: NIH RePORTER
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Damage to RNA from ultraviolet light, oxidation, chlorination, nitration, and akylation can include chemical modifications to nucleobases as well as RNA-RNA and RNA-protein crosslinking. In vitro studies have described a range of possible damage products, some of which are supported as physiologically relevant by in vivo observations in normal growth, stress conditions, or disease states. Damage to both messenger RNA and noncoding RNA may have functional consequences, and work has begun to elucidate the role of RNA turnover pathways and specific damage recognition pathways in clearing cells of these damaged RNAs.
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