Journal
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume 44, Issue 5, Pages 343-351Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10409230903232618
Keywords
Chromosome domain; epigenetics; histone acetylation; nuclear position; replication timing
Categories
Funding
- Spanish Ministry of Science and Innovation [BFU2007-65326, CSD2007-0015]
- European Union [IRG FP6-031129]
- Fundacion Caja Madrid
Ask authors/readers for more resources
Eukaryotic cells follow a temporal program to duplicate their genomes. Chromosomes are divided into domains with a specific DNA replication timing (RT), not dictated by DNA sequence alone, which is conserved from one cell cycle to the next. Timing of replication correlates with gene density, transcriptional activity, chromatin structure and nuclear position, making it an intriguing epigenetic mark. The differentiation from embryonic stem cells to specialized cell types is accompanied by global changes in the RT program. This review covers our current understanding of the mechanisms that determine RT in mammalian cells, its possible biological significance and how unscheduled alterations of the RT program may predispose to human disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available