Journal
CRITICAL CARE MEDICINE
Volume 38, Issue -, Pages S676-S682Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CCM.0b013e3181f2458d
Keywords
critical illness; muscle weakness; muscle protein turnover; muscle-signaling pathways
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Funding
- Department of Health [DRF-2010-03-114] Funding Source: Medline
- National Institute for Health Research [DRF-2010-03-114] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [DRF-2010-03-114] Funding Source: National Institutes of Health Research (NIHR)
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Understanding the trajectory of skeletal muscle loss, evaluating its relationship to the subsequent functional impairment, and understanding the underlying mechanisms of skeletal muscle wasting will provide goals for novel treatment strategies in the intensive care setting. A focused approach on the effect of critical illness on muscle morphology, muscle protein turnover, and the associated muscle-signaling pathways during the early and recovery stages of critical illness is required. This could potentially lead to targeted pharmacologic and nonpharmacologic strategies to treat, or even prevent, peripheral muscle wasting and weakness. (Crit Care Med 2010; 38[Suppl.]: S676-S682)
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