Journal
CRITICAL CARE MEDICINE
Volume 38, Issue 5, Pages 1261-1269Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CCM.0b013e3181d9d87a
Keywords
glucagon-like peptide 1; blood glucose; hyperglycemia; critical illness; gastric emptying; enteral nutrition
Categories
Funding
- National Health and Medical Research Council of America
- National Health and Medical Research Council of Australia [508081]
- University of Adelaide/Royal Adelaide Hospital
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Objective: To determine the acute effects of exogenous glucagon-like peptide-1 on gastric emptying, glucose absorption, glycemia, plasma insulin, and glucagon in critically ill patients. Design: Randomized, double-blind, crossover study. Setting: Intensive care unit. Subjects: Twenty-five mechanically ventilated patients, without known diabetes, studied on consecutive days. Interventions: Intravenous glucagon-like peptide-1 (1.2 pmol/kg/ min) or placebo was infused between -30 and 330 mins. At 0 min, 100 mL liquid nutrient (1 kcal/mL) including 100 mu g of (13)C-octanoic acid and 3 grams of 3-0-methyl-glucose was administered. Measurements and Main Results: Blood glucose, serum 3-0-methyl-glucose (as an index of glucose absorption), insulin and glucagon concentrations, as well as exhaled (13)CO(2) were measured. The gastric emptying coefficient was calculated to quantify gastric emptying. Data are presented as mean (SD). There was a nonsignificant trend for glucagon-like peptide-1 to slow gastric emptying (gastric emptying coefficient) (glucagon-like peptide-1, 2.45 [0.93] vs. placebo, 2.75 [0.83]; p = .09). In 11 of the 25 patients, gastric emptying was delayed during placebo infusion and glucagon-like peptide-1 had no detectable effect on gastric emptying in this group (1.92 [0.82] vs. 1.90 [0.68]; p = .96). In contrast, in patients who had normal gastric emptying during placebo, glucagon-like peptide-1 slowed gastric emptying substantially (2.86 [0.58] vs. 3.41 [0.37]; p = .006). Glucagon-like peptide-1 markedly reduced the rate of glucose absorption (3-0-methyl-glucose area under the curve(0-330), 37 [35] vs. 76 [51] mmol/L/min; p < .001), decreased preprandial glucagon (at 0 min change in glucagon, -15 [15] vs. -3 [14] pmol/L; p < .001), increased the insulin/glucose ratio throughout the infusion (area under the curve(-30-330), 1374 [814] vs. 1172 [649] mU/mmol/min; p = .041), and attenuated the glycemic response to the meal (glucose area under the curve(0-330), 2071 [353] vs. 2419 [594] mmol/L/min; p = .001). Conclusions: Exogenous glucagon-like peptide-1 lowers post-prandial glycemia in the critically ill. This may occur, at least in part, by slowing gastric emptying when the latter is normal but not when it is delayed. (Crit Care Med 2010; 38:1261-1269)
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