Journal
CRITICAL CARE MEDICINE
Volume 36, Issue 4, Pages 1290-1296Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CCM.0b013e3181692dfc
Keywords
brain hypoxia; cerebral oxygenation; erythrocytes; neurotrauma; brain tissue oxygen pressure; red blood cells; severe brain injury; transfusion
Categories
Ask authors/readers for more resources
Objective: Prolonged erythrocyte storage time might reduce the efficacy of transfusion. In this study, the effects of transfusion of erythrocytes with four different storage periods (<10 days, In = 18; 10-14 days, n = 15; 15-19 days, n = 17; and >19 days, n = 16 patients) on brain tissue oxygen tension (Ptio(2)) in stable male patients with severe traumatic brain injury were investigated during a 24-hr follow-up period. Design: Prospective, observational study. Setting. Neurotrauma critical care unit of a university hospital. Patients: Sixty-six male, nonbleeding, hemodynamically stable anemic patients (hemoglobin <95 g/L) with Glasgow Coma Scale score <9. Interventions: None: Measurements and Main Results. Ptio(2), cerebral perfusion pressure, mean arterial pressure, intracranial pressure, peripheral oxygen saturation, CO2 pressure at the end of expiration, and intracerebral temperature were recorded in all patients at baseline, immediately after the completion of transfusion, and 1, 2, 3, 4, 5, 6,12, and 24 hrs posttransfusion. All four groups were homogeneous with respect to multiple baseline variables, except for storage time of transfused erythrocytes (p <.0001). There was a significant short-lasting (3-4 hrs) increase in Ptio(2) values after transfusion of erythrocytes stored for <10 days, 10-14 days, or 15-19 days, compared with those at baseline. In contrast, no significant changes in Ptio(2) were observed after transfusion of erythrocytes stored >19 days. Conclusions. Transfusion of erythrocytes increased cerebral oxygenation in patients with severe traumatic brain injury, except in those transfused with erythrocytes stored > 19 days.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available