Journal
CRITICAL CARE CLINICS
Volume 28, Issue 2, Pages 231-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccc.2011.10.012
Keywords
Cardiac arrest; Cardiopulmonary resuscitation; Hypothermia; Neurologic function
Categories
Funding
- American Heart Association [11IRG 487001]
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Mild therapeutic hypothermia (32 degrees C-34 degrees C) has been shown to improve survival and neurologic outcomes after sudden cardiac arrest in clinical studies. Its use is recommended by the American Heart Association for unconscious adult patients with spontaneous circulation after out-of-hospital ventricular fibrillation. It decreases cerebral metabolism and protects the brain after ischemia by reduction of brain metabolism, attenuation of neuroexcitotoxic cascade, abolition of reactive oxygen species, and inhibition of apoptosis. This article addresses the mechanism of neuroprotection, phases of hypothermia, and noninvasive and invasive cooling methods.
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