Journal
CRITICAL CARE CLINICS
Volume 26, Issue 3, Pages 549-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccc.2010.04.005
Keywords
Critical illness; Intestine; Growth factors
Categories
Funding
- National Institutes of Health [GM66202, GM072808, F32 GM082008]
- Shock Society
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The intestine plays a central role in the pathophysiology of critical illness and is frequently called the motor of the systemic inflammatory response. Perturbations to the intestinal barrier can lead to distant organ damage and multiple organ failure. Therefore, identifying ways to preserve intestinal integrity may be of paramount importance. Growth factors and other peptides have emerged as potential tools for modulation of intestinal inflammation and repair due to their roles in cellular proliferation, differentiation, migration, and survival. This review examines the involvement of growth factors and other peptides in intestinal epithelial repair during critical illness and their potential use as therapeutic targets.
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