4.6 Article

The role of human basolateral amygdala in ambiguous social threat perception

Journal

CORTEX
Volume 52, Issue -, Pages 28-34

Publisher

ELSEVIER MASSON
DOI: 10.1016/j.cortex.2013.12.010

Keywords

Amygdala; Body emotion expressions; Urbach-Wiethe disease; Emotion; Basolateral amygdala

Funding

  1. project TANGO
  2. Future and Emerging Technologies (PET) programme within the Seventh Framework Programme for Research of the European Commission [249858]
  3. European Research Council [295673]
  4. Hope For Depression Research Foundation (HDR_F: RGA) [9-015]
  5. Netherlands Society of Scientific Research (Brain and Cognition) [056 24-010]
  6. South African MRC/DST Professional Development Program
  7. University of Cape Town (Brain Behavior Initiative)
  8. John D. and Catherine T. MacArthur Foundation Research Network on Early Experience and Brain Development
  9. European Research Council (ERC) [295673] Funding Source: European Research Council (ERC)

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Previous studies have shown that the amygdala (AMG) plays a role in how affective signals are processed. Animal research has allowed this role to be better understood and has assigned to the basolateral amygdala (BLA) an important role in threat perception. Here we show that, when passively exposed to bodily threat signals during a facial expressions recognition task, humans with bilateral BLA damage but with a functional central-medial amygdala (CMA) have a profound deficit in ignoring task-irrelevant bodily threat signals. (C) 2014 Elsevier Ltd. All rights reserved.

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