Journal
CORTEX
Volume 61, Issue -, Pages 64-73Publisher
ELSEVIER MASSON, CORPORATION OFFICE
DOI: 10.1016/j.cortex.2014.07.019
Keywords
Anosognosia; Alzheimer's disease; Awareness; Insight; Self-knowledge
Funding
- Australian National Health and Medical Research Council [458677]
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Anosognosia is present in a large proportion of patients with mild Alzheimer's-disease (AD), and its frequency increases with the progression of the illness. Several instruments have been validated to assess anosognosia in AD, but there is no consensus regarding the best diagnostic strategy. Anosognosia in AD is a significant predictor of apathy and is significantly related to lower depression and anxiety scores, more severe caregiver burden and dangerous behaviours. Studies using different imaging modalities have demonstrated an association between anosogmosia and dysfunction in frontal, temporomedial and temporoparietal regions. The mechanism of anosognosia remains unknown, but it has been explained as a consequence of deficits of encoding and updating biographical memory, and dysfunction of comparator, executive and metacognitive systems. (C) 2014 Elsevier Ltd. All rights reserved.
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