Journal
JOURNAL OF NANOPARTICLE RESEARCH
Volume 17, Issue 4, Pages -Publisher
SPRINGER
DOI: 10.1007/s11051-015-3008-3
Keywords
Doxorubicin; Super paramagnetic iron oxide nanoparticles; Protein corona; Mesoporous silica; Nanomedicine
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In the present work, biocompatible superparamagnetic iron oxide nanoparticles coated by mesoporous silica were used as drug nanocarriers for doxorubicin (Dox; an anticancer drug) delivery. In biological media, the interaction of protein corona layer with the surface of nanoparticles is inevitable. For this reason, we studied the effect of protein corona on drug release from magnetic mesoporous silica nanoparticles (MMSNs) in human plasma medium. Besides, we used hydrophilic and biocompatible polymer, polyethylene glycol (PEG), to decrease protein corona effects. The results showed the increased Dox release from PEGylated MMSNs compared with bare MMSNs. This result indicated that the coating of PEG reduced the wrapping of the protein corona around the nanoparticles. This phenomenon caused increase in Dox release.
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