Combined Topical Application of a Regenerative Agent With a Bandage Contact Lens for the Treatment of Persistent Epithelial Defects

Purpose: The aim of this study was to report 3 cases of persistent epithelial defects (PEDs) successfully treated with the combined topical application of a regenerative agent (RGTA; Cacicol20, OTR3, Paris, France) with a bandage contact lens (BCL). Methods: This is a case series. Results: Three patients suffering from a PED for 4-8 weeks and unresponsive to conventional therapy were treated with the combined application of an RGTA (Cacicol20) and a silicone hydrogel BCL. The PED healed in all patients after 4-21 days, and no side effects were noted. Conclusions: The combination of an RGTA (Cacicol20) with a BCL seems to be an effective treatment for PED.