Journal
CORNEA
Volume 27, Issue 7, Pages 782-786Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/ICO.0b013e31816f5ec3
Keywords
confocal microscopy; limbus; niche; Vogt palisades; basal cells
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Funding
- Major Project of Clinical Specialty for Ministry of Health Subordinate Hospitals
- Scientific Research Grants of Bureau Public Health of Shanghai
- Health and Science Grants of Bureau Social Development of Pudong New Area
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Purpose: To show age-related changes in the presence of Vogt palisades in human limbus and the quantity and size of the limbal basal epithelial cells (LBECs) by in vivo confocal microscopy (CM). Methods: One hundred sixty eyes of 160 healthy subjects were enrolled in this study after a routine slit-lamp examination. They were divided into 4 groups according to age: A (0-19 years), B (2039 years), C (40-59 years), and D (> 60 years). In vivo CM examination was performed on the inferior limbus, and the images were recorded. For each group, the positive rate of Vogt palisades was analyzed and the average size of LBECs was measured. Results: The positive rate of Vogt palisades in groups A, B, C, and D was 97.5% (39/40), 95.0% (38/40), 77.5% (31/40), and 40.0% (16/40), respectively, showing a significant decreasing tendency with age. The average size of LBECs in groups A, 13, C, and D was 9.89 +/- 1.12, 10.65 +/- 1.45, 10.70 +/- 1.39, and 12.36 +/- 1.68 mu m. Significant differences between groups were obvious except for that between groups B and C. Conclusions: The presence of Vogt palisades in human limbus declined with age. Therefore, so did the qualities of LBECs, with an age-related cell size enlargement.
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