Journal
COORDINATION CHEMISTRY REVIEWS
Volume 268, Issue -, Pages 1-22Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2014.01.016
Keywords
Targeting vectors; Glucose; Sialic acid; Glycated proteins; Polyols; Preorganization
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The general principles of interaction between bor(on)ic acids and sugars in aqueous media are discussed with a focus on the structural aspects that play a role with respect to the regioselectivity of the interactions and the stability of the resulting adducts. Preorganization and pK(a) s appear to play important roles. Glucose and sialic acid will be demonstrated to be the promising targets for artificial B-based sensors. These sugars are important markers for diabetes and cancer, respectively. (C) 2014 Elsevier B.V. All rights reserved.
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