Journal
COORDINATION CHEMISTRY REVIEWS
Volume 281, Issue -, Pages 100-113Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2014.09.005
Keywords
Metal complexes; DNA condensation; Gene delivery; Anticancer agents
Categories
Funding
- 973 Programme [2014CB845604]
- NSFC [21172273, 21171177, 91122010]
- Programme for Changjiang Scholars and Innovative Research Team at the University of China [IRT1298]
- Research Fund for the Doctoral Programme of Higher Education [20110171110013]
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DNA is stored in a highly compact, condensed phase in viruses, bacteria and eukaryotes. Co(NH3)(6)(3+) is a well-known inorganic cation that can induce DNA condensation, and numerous Co(III), Co(II), Fe(II),Ca(II), Cu(II), Ni(II), Zn(II), Ru(II), Pt(II) and La(III) complexes have been evaluated as DNA condensing agents. In this review, we divided these metal complexes into four distinct classes based on the mechanism of DNA condensation: (i) complexes with high positive charges that condense DNA via electrostatic interaction, (ii) complexes with planar intercalative ligands that condense DNA via pi-pi interaction, (iii) complexes that bind with DNA through hydrogen bonds, and (iv) complexes that covalently bind to DNA. Some applications of these metal complex-based DNA condensing agents in gene vectors and antitumor agents are also presented. (C) 2014 Elsevier B.V. All rights reserved.
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