Photochemically activated carbon monoxide release for biological targets. Toward developing air-stable photoCORMs labilized by visible light

The potential therapeutic effects of carbon monoxide in several disease states, and new methodologies for CO delivery to specific targets is a topic of growing interest in mammalian physiology. Here we provide an overview of recent efforts in this laboratory regarding several types of carbonyl complexes of the group 6 metal and of those in other laboratories that are focused on developing photochemical techniques for such CO delivery. Photo-activated carbon monoxide releasing moieties (photoCORMs) based on manganese, iron and group 6 metals are described. (C) 2011 Elsevier B.V. All rights reserved.