Journal
COORDINATION CHEMISTRY REVIEWS
Volume 255, Issue 7-8, Pages 688-699Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2010.10.016
Keywords
Iron-sulfur cluster; Assembly; Biosynthesis; ISU/IscU; Frataxin; NFS/IscS
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Funding
- National Institutes of Health [AI072443]
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Iron-sulfur clusters are an important class of protein-bound prosthetic center that find wide utility in nature. Roles include electron transfer, enzyme catalysis, protein structure stabilization, and regulation of gene expression as transcriptional and translational sensors. In eukaryotes their biosynthesis requires a complex molecular machinery that is located within the mitochondrion, while bacteria exhibit up to three independent cluster assembly pathways. All of these paths share common themes. This review summarizes some key structural and functional properties of three central proteins dedicated to the Fe-S cluster assembly process: namely, the sulfide donor (cysteine desulfurase); iron donor (frataxin), and the iron-sulfur cluster scaffold protein (IscU/ISU). (C) 2010 Elsevier B.V. All rights reserved.
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