Journal
COORDINATION CHEMISTRY REVIEWS
Volume 252, Issue 5-7, Pages 659-701Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2007.10.031
Keywords
biocatalysis; enzymatic processes; chiral intermediates; drugs synthesis
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Chirality is a key factor in the safety and efficacy of many drug products and thus the production of single enantiomers of drug intermediates has become increasingly important in the pharmaceuticals industry. There has been an increasing awareness of the enormous potential of microorganisms and enzymes derived therefrom for the transformation of synthetic chemicals with high chemo-, regio- and enatio-selectivities. In this article, biocatalytic processes are described for the synthesis of chiral intermediates for pharmaceuticals. (c) 2007 Elsevier B.V. All rights reserved.
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