Journal
CONTRAST MEDIA & MOLECULAR IMAGING
Volume 10, Issue 2, Pages 96-110Publisher
WILEY-HINDAWI
DOI: 10.1002/cmmi.1615
Keywords
boron; fluorine-18; radiolabelling; fluoroborates; BODIPY; PET
Funding
- Daisy Appeal charity [DAhul0211]
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Standard [F-18]fluorination methods to form carbon-fluorine bonds can have some limitations such as low yield and the requirement for harsh reaction conditions. Inorganic approaches include the formation of boron-[F-18]fluorine bonds and have the potential to give high specific activities at room temperature forming a bond that is stablein vivo. There is considerable potential in future applications, particularly in relation to multimodal imaging and the provision of rapid efficient labelling protocols. Copyright (c) 2014 John Wiley & Sons, Ltd.
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