Journal
CONTRAST MEDIA & MOLECULAR IMAGING
Volume 7, Issue 1, Pages 26-34Publisher
WILEY-HINDAWI
DOI: 10.1002/cmmi.460
Keywords
PARACEST; MRI; contrast agent; pH
Funding
- Arizona Cancer Center
- Case Center for Imaging Research
- National Cancer Institute [CA110943, CA 023074, CA 017094, CA133455-01]
- US Army Medical Research and Materiel Command [W81XWH-09-1-0053]
- CWRU MSTP under NIH [T32 GM007250]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [840336] Funding Source: National Science Foundation
Ask authors/readers for more resources
The measurement of extracellular pH has potential utility for assessing the therapeutic effects of pH-dependent and pH-altering therapies. A PARAmagnetic chemical exchange saturation transfer (PARACEST) MRI contrast agent, YbDO3AoAA, has two CEST effects that are dependent on pH. A ratio derived from these CEST effects was linearly correlated with pH throughout the physiological pH range. The pH can be measured with a precision of 0.21 pH units and an accuracy of 0.09 pH units. The pH measurement is independent of concentration and T1 relaxation times, but is dependent on temperature. Although MR coalescence affects the CEST measurements, especially at high pH, the ratiometric analysis of the CEST effects can account for incomplete saturation of the agent's amide and amine that results from MR coalescence. Provided that an empirical calibration is determined with saturation conditions, magnetic field strength and temperature that can be used for subsequent studies, these results demonstrate that this single PARACEST MRI contrast agent can accurately measure pH. Copyright (c) 2012 John Wiley & Sons, Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available