Journal
CONTRAST MEDIA & MOLECULAR IMAGING
Volume 5, Issue 4, Pages 231-236Publisher
WILEY-HINDAWI
DOI: 10.1002/cmmi.376
Keywords
molecular imaging, cellular uptake, MRI; CT, contrast agents; paramagnetic agents, fluorescent probes, trimodal probes, nanoparticles
Funding
- NIH/NCI [5R24 CA095823-04]
- NSF [DBI-9724504]
- NIH [1 S10 RRO 9145-01]
- NIH/NHLBI [R01 HL71021]
- Kf Hein Fonds and KWF Kankerbestijding
- AHA Founder's Affiliate [09POST2220194]
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An important challenge in medical diagnostics is to design all-in-one contrast agents that can be detected with multiple techniques such as magnetic resonance imaging (MRI), X-ray computed tomography (CT), positron emission tomography (PET), single photon emission tomography (SPECT) or fluorescence imaging (FI). Although many dual labeled agents have been proposed, mainly for combined MRI/FI, constructs for three imaging modalities are scarce. Here gold/silica nanoparticles with a poly(ethylene glycol), paramagnetic and fluorescent lipid coating were synthesized, characterized and applied as trimodal contrast agents to allow for nanoparticle-enhanced imaging of macrophage cells in vitro via MRI, CT and FI, and mice livers in vivo via MRI and CT. This agent can be a useful tool in a multitude of applications, including cell tracking and target-specific molecular imaging, and is a step in the direction of truly multi-modal imaging. Copyright (C) 2010 John Wiley & Sons, Ltd.
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