Designing, syntheses, characterization, computational study and biological activities of silver-phenothiazine metal complex

A noble biologically active compound Ag(I)-PTZ metal complex (1) with spherical morphology was synthesized first time. Entire characterization tool (spectral, elemental, mass and thermal analysis) was supported a distorted tetrahedral structure, where two water compounds were coordinated with Ag(I) including one phenothiazine and one nitrate group. For the better insight, obtained spectral/structural results were supported by 3D molecular modeling. Compound 1 had shown excellent activities against the Salmonella typhimurium and Aspergillus fumigatus with minimum inhibitory concentration (MIC) value 20 mg/L and 25 mg/L. The observed antioxidant radical scavenging activity (in %) of compound 1 (62.74%) was more than control ascorbic acid (28.58%). The observed protein (BSA) binding constant of 1 was 8.86 x 10(4) M-1, which is similar to binding constant of salicylic acid with BSA protein. Initial studies have revealed that synthesized compound 1 may act as multipurpose drug analogue in future. (C) 2015 Elsevier B.V. All rights reserved.