Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1099, Issue -, Pages 18-23Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2015.05.054
Keywords
FOR spectroscopy; IR spectra; Liver cancer; Cell
Categories
Funding
- key project of fund for outstanding young talents in higher education institutions of Anhui Province [2013SQRL021 ZD]
- Anhui Provincial Natural Science Foundation [1408085QH154]
- Grants for scientific research of BSKY from Anhui Medical University [XJ201228]
- Grants for the third group of young and middle-aged academic backbone of Anhui Medical University
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Since liver cancer seriously threatens human health, it is very urgent to explore an effective method for diagnosing liver cancer early. In this study, we investigated the structure differences of IR spectra between neoplastic liver cells and normal liver cells. The major differences of absorption bands were observed between liver cancer cells and normal liver cells, the values of A2955/A2921, A1744/A1082, A1640/A1535, H1121/H1020 might be potentially useful factors for distinguishing liver cancer cells from normal liver cells. Curve fitting also provided some important information on structural differences between malignant and normal liver cancer cells. Furthermore, IR spectra combined with hierarchical cluster analysis could make a distinction between liver cancer cells and normal liver cells. The present results provided enough cell basis for diagnosis of liver cancer by FTIR spectroscopy, suggesting FTIR spectroscopy may be a potentially useful tool for liver cancer diagnosis. (C) 2015 Elsevier B.V. All rights reserved.
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