Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1099, Issue -, Pages 432-440Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2015.06.077
Keywords
Platinum nanoparticles; Photodynamic antimicrobial chemotherapy; Carboxyphenoxy porphyrin; S. aureus
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Funding
- Department of Science and Technology (DST)
- National Research Foundation (NRF) of South Africa through DST/NRF South African Research Chairs Initiative for Professor of Medicinal Chemistry and Nanotechnology [UID 62620]
- Rhodes University
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This work reports on the conjugation of differently shaped Pt nanoparticles (PtNPs) with ClGa(III) 5,10,15,20-tetrakis-(4-carboxyphenyl) porphyrin (ClGaTCPP). The resulting conjugates were used for photodynamic antimicrobial chemotherapy against Staphylococcus aureus. The degree of photo-inactivation is dependent on concentration of the conjugates, light dose (fluence) and illumination time. The log reduction obtained for ClGaTCPP when conjugated to cubic PtNPs was 4.64 log (which indicate 99.99% of the bacteria have been killed), which is much higher than 3.94 log unit for ClGaTCPP-Hexagonal PtNPs and 3.31 log units for ClGaTCPP-Unshaped PtNPs. ClGaTCPP alone gave a log unit reduction of less than 3, showing the importance of conjugation to PtNPs. (C) 2015 Elsevier B.V. All rights reserved.
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