Journal
CONTEMPORARY CLINICAL TRIALS
Volume 32, Issue 2, Pages 240-243Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cct.2010.11.004
Keywords
Bias; Blinding; Double blind; Masking; Randomized controlled trial; Single blind; Triple blind
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The use of blinding strengthens the credibility of randomized controlled trials (RCTs) by minimizing bias. However, there is confusion surrounding the definition of blinding as well as the terms single, double, and triple blind. It has been suggested that these terms should be discontinued due to their broad misinterpretation. We recommend that, instead of abandoning the use of these terms, explicit definitions of blinding should be adopted. We address herein the concept of blinding, propose standard definitions for the consistent use of these terms, and detail when different types of blinding should be utilized. Standardizing the definition of blinding and utilizing proper blinding methods will improve the quality and clarity of reporting in RCTs. (C) 2010 Elsevier Inc. All rights reserved.
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