Journal
CONTACT DERMATITIS
Volume 62, Issue 5, Pages 279-288Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0536.2010.01709.x
Keywords
chemical analyses; dimethylglyoxime test; nickel release; sensitivity; specificity; validation
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Funding
- Horslev Foundation, Denmark
- Swedish Council for Working Life and Social Research
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Objectives: To evaluate the sensitivity and specificity of the DMG test. Methods: DMG spot testing, chemical analysis according to the EN 1811 reference method, and X-ray fluorescence spectroscopy (XRF) were performed concomitantly on 96 metallic components from earrings recently purchased in San Francisco. Results: The sensitivity of the DMG test was 59.3% and the specificity was 97.5% based on DMG-test results and nickel release concentrations determined by the EN 1811 reference method. Conclusions: The DMG test has a high specificity but a modest sensitivity. It may serve well for screening purposes. Past exposure studies may have underestimated nickel release from consumer items.
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