Journal
CONTACT DERMATITIS
Volume 61, Issue 4, Pages 201-208Publisher
WILEY
DOI: 10.1111/j.1600-0536.2009.01607.x
Keywords
dose-response; elicitation; patch test; repeated exposure; ROAT
Categories
Funding
- Aage Bangs foundation
- NiPERA (Nickel Producers Environmental Research Association)
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Background Allergic contact dermatitis is common and can be prevented. The relationship between thresholds for patch tests and the repeated open application test (ROAT) is unclear. It would be desirable if patch test and ROAT data from already sensitized individuals could be used in prevention. Objectives The aim was to develop an equation that could predict the response to an allergen in a ROAT based on the dose-response curve derived by patch testing. Materials/methods Results from two human experimental elicitation studies with non-volatile allergens, nickel and the preservative methyldibromo glutaronitrile (MDBGN), were analysed by logistic dose-response statistics. The relation for volatile compounds was investigated using the results from experiments with the fragrance chemicals hydroxyisohexyl 3-cyclohexene carboxaldehyde and isoeugenol. Results For non-volatile compounds, the outcome of a ROAT can be estimated from the patch test by: EDxx(ROAT) = 0.0296 EDxx(patch test). For volatile compounds, the equation predicts that the response in the ROAT is more severe than the patch test response, but it overestimates the response. Conclusions This equation may be used for non-volatile compounds other than nickel and MDBGN, after further validation. The relationship between the patch test and the ROAT can be used for prevention, to set safe levels of allergen exposure based on patch test data.
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