Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1097, Issue -, Pages 199-206Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2015.05.018
Keywords
Cyclonucleosides; 6,5 '-O-anhydrouridine; Constrained molecules; Intermolecular interactions
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Funding
- Polish Ministry of Science and Higher Education [IP2010 026070]
- EC [POKL 4.1.2-107/09]
- Centre for Preclinical Research and Technology (CePT)
- European Regional Development Fund
- Innovative Economy, The National Cohesion Strategy of Poland
- European Union from the European Regional Development Fund under the Operational Programme Innovative Economy
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A series of analogues of anhydrouridine have been synthesized and their crystal structures established using X-ray diffraction. For all cases, the ribose ring has 0(4')-exo, C(4')-endo pucker and the pyrimidine base is in the anti conformation. Investigated compounds crystallize in different crystal systems (monoclinic, orthorhombic), have different space group symmetry (P2(1), P2(1)2(1)2(1)) and exhibit different intermolecular interactions (halogen and hydrogen bonds) among molecules in their crystal lattices. Moreover, in the case of the 5-benzyl-6,5'-O-anhydrouridine a significant positional disorder is present with the phenyl rings existing in two orientations. (C) 2015 Elsevier B.V. All rights reserved.
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