Insulin-like action of novel metformin-containing vanadate as a new antidiabatic drug: Synthesis, characterization and crystal structure of [Metformin-H]2[V2O6] ]•H2O

A new vanadate compound, which contains interlamellary, the insulin enhancing agent metformin was prepared. Its structure was established to be [Metformin](2)[V2O6]center dot H2O 1 by using elemental analysis, FT-IR and H-1-C-13 NMR spectroscopic methods. The crystal structure of 1 shows that each of the two vanadium atoms is coordinated to four oxygen atoms, forming a distorted tetrahedral {VO4} that are arranged alternately to form one-dimension {V2O6}(n)(2n-) chains. The chains are stabilized by an extensive hydrogen bonding involving oxide ligands of the chains and metformin molecules which fill the space between the stacks of chains. Furthermore, powder X-ray diffraction, EDX-SEM and TGA-DTA analysis of compound 1 are also investigated, which demonstrates its high purity and thermal stability. The thermoanalytical data evidence that compound 1 undergo complete decomposition, resulting in V2O5 as a residual product. Investigation of the glucose lowering activity by oral administration of compound 1 in streptozotocin-induced diabetic rats was examined. (C) 2015 Elsevier B.V. All rights reserved.