Journal
JOURNAL OF MOLECULAR RECOGNITION
Volume 28, Issue 11, Pages 667-678Publisher
WILEY
DOI: 10.1002/jmr.2482
Keywords
surface acoustic wave (SAW) sensor; molecularly Imprinted Polymer (MIP); dopamine; atomic force microscopy (AFM); DFT calculations
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Funding
- GENCI-[CCRT/CINES/IDRIS] [2015-[c2015087006]]
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A surface acoustic wave sensor operating at 104MHz and functionalized with a polypyrrole molecularly imprinted polymer has been designed for selective detection of dopamine (DA). Optimization of pyrrole/DA ratio, polymerization and immersion times permitted to obtain a highly selective sensor, which has a sensitivity of 0.55 degrees/mM (approximate to 550Hz/mM) and a detection limit of approximate to 10nM. Morphology and related roughness parameters of molecularly imprinted polymer surfaces, before and after extraction of DA, as well as that of the non imprinted polymer were characterized by atomic force microscopy. The developed chemosensor selectively recognized dopamine over the structurally similar compound 4-hydroxyphenethylamine (referred as tyramine), or ascorbic acid,which co-exists with DA in body fluids at a much higher concentration. Selectivity tests were also carried out with dihydroxybenzene, for which an unexpected phase variation of order of 75% of the DA one was observed. Quantum chemical calculations, based on the density functional theory, were carried out to determine the nature of interactions between each analyte and the PPy matrix and the DA imprinted PPy polypyrrole sensing layer in order to account for the important phase variation observed during dihydroxybenzene injection. Copyright (c) 2015 John Wiley & Sons, Ltd.
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